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Monday 17 February 2020

Twenty four genetic variants linked to heightened womb cancer risk

Twenty four common variations in genes coding for cell growth and death, the processing of oestrogen, and gene control factors may be linked to a heightened risk of developing womb (endometrial) cancer, indicates the most comprehensive review of the published evidence so far in the Journal of Medical Genetics.

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Mediterranean diet promotes gut bacteria linked to 'healthy ageing' in older people

Eating a Mediterranean diet for a year boosts the types of gut bacteria linked to 'healthy' ageing, while reducing those associated with harmful inflammation in older people, indicates a five-country study, published online in the journal Gut.

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Complications of measles can include hepatitis, appendicitis, and viral meningitis, doctors warn

The complications of measles can be many and varied, and more serious than people might realise, doctors have warned in the journal BMJ Case Reports after treating a series of adults with the infection.

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Study investigates rates of adverse events for common rheumatoid arthritis drug

Methotrexate is a common drug with a long history; for the past 40 years, it's been used to treat a range of diseases. Today it is the most commonly used drug for systemic rheumatic diseases worldwide and is the first drug a physician will prescribe for a patient with rheumatoid arthritis. But despite its use by millions of people, there is not robust data on the rates of the side effects of the drug. Observational studies have suggested that methotrexate may elevate a person's risk of a variety of adverse events, including liver toxicity, anemia and difficulty in breathing, but the magnitude of risk was unknown. Taking advantage of data from the Cardiovascular Inflammation Reduction Trial (CIRT), a randomized double-blind, placebo-controlled trial, investigators from Brigham and Women's Hospital have been able to far more accurately determine rates of adverse events for people taking methotrexate, finding small-to-moderate elevations in risks for skin cancer, gastrointestinal, infectious, lung, and blood adverse events. Results are published in Annals of Internal Medicine.

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New VA/DoD guidelines address sleep-related issues in military personnel, veterans

Recognizing and addressing the widespread problem of sleep disorders in military personnel and veterans, the U.S. Departments of Veterans Affairs and Defense (VA/DoD) jointly have issued new guidelines for assessment and treatment of insomnia and obstructive sleep apnea.